Recombinant CD22 Monoclonal Antibody

Size

£170.10

Was £189.00

SKU:: AN300016P
Additional Names:: Lyb,SIGLEC2FLJ,B-cell receptor CD,T-cell surface antigen Leu,sialic acid binding Ig-like lectin,Sialic acid-binding Ig-like lectin,CD22,SIGLEC-2,SIGLEC2,B-cell receptor CD22,BL-CAM,B-lymphocyte cell adhesion molecule,CD22 antigenMGC130020,CD22 molecule,Lyb-8,sialic acid binding Ig-like lectin 2,Sialic acid-binding Ig-like lectin 2,SIGLEC2FLJ22814,T-cell surface antigen Leu-14,Siglec-2,CD22 molecule,B cell receptor CD22 precursor,B lymphocyte cell adhesion molecule,BL CAM,BLCAM,CD 22,CD22
Application:: IHC-P
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS
Immunogen:: Recombinant Human CD22 protein
Clone:: A1126
Uniprot:: P20273
Synonyms:: B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;CD22 antigen;sialic acid-binding Ig-like lectin 2;SIGLEC-2;SIGLEC2;T-cell surface antigen Leu-14
Extra Details:: Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or Blymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.

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