AN200188P
CD113/Nectin-3 Monoclonal Antibody
Size
£311.40
Was £346.00
- SKU:
- AN200188P
- Additional Names:
- PRR,CDw,PPR,PVRL,Poliovirus receptor-like,Poliovirus receptor related,Poliovirus receptor related protein,PVRR,DKFZP566B,CD113,CDw113,DKFZP566B0846,FLJ90624,Nectin-3,Poliovirus receptor related 3,Poliovirus receptor related protein 3,Poliovirus receptor-like 3,Poliovirus Receptor-Related Protein 3,PPR3,PVRR3,PRR3,PVRL3,NECTIN3,Nectin-3,PRR3,CDw113
- Application:
- IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human CD113/Nectin-3 protein
- Clone:
- A1040
- Uniprot:
- Q9NQS3
- Synonyms:
- CD113;CDW113;nectin 3;Nectin cell adhesion molecule 3;nectin-3;poliovirus receptor-related 3;poliovirus receptor-related protein 3;PPR3;PRR3;PVRL3;PVRR3
- Extra Details:
- Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation.
- Shipping Conditions:
- Blue Ice