IL17RA/CD217 Monoclonal Antibody

Size

£311.40

Was £346.00

SKU:: AN200111P
Additional Names:: IMD,MGC,CTLA,CANDF,CDw,IL17RA,CANDF5,CD217,CDw217,IL-17RA,IL17R,IMD51,hIL-17R,CD127,CD217 antigen,CDW127,CTLA8,HIL 17R,hIL17R,I17RA,IL 17 receptor,IL 17 receptor A,IL 17RA,IL17,IL-17 R alpha,IL-17 receptor A,IL17A receptor,IL-17R,IL17R-A,IL17-RA,IL-17R-alpha,IL7RA,ILRA,Interleukin 17 receptor A,Interleukin-17 receptor A,MGC10262,CDw217,Interleukin-17 receptor A
Application:: WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: Recombinant Human IL17RA protein
Clone:: A959
Uniprot:: Q96F46
Synonyms:: CANDF5;CD217;CDw217;hIL-17R;IL-17 receptor A;IL-17RA;IL17R;IMD51;interleukin-17 receptor A
Extra Details:: Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleotropic cytokine. IL-17 binds to IL-17 receptor A (IL-17 RA), also known as IL-17 receptor (IL-17 R). IL-17 RA shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 RA mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL-17 RA is a 120 kDa, 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. Within the ECD, human IL-17 RA shares 72% aa sequence identity with mouse and rat IL-17 RA. The signaling events of IL-17 includes activation of NF-kappa B and JNK, and require TNF receptor-associated factors 6 (TRAF6) in the signaling pathway.

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