AN200036P
IL-1RA/IL1RN Monoclonal Antibody
Size
£311.40
Was £346.00
- SKU:
- AN200036P
- Additional Names:
- IL1F,MVCD,IL1RN,DIRA,ICIL-1RA,IL-1RN,IL-1ra,IL-1ra3,IL1F3,IL1RA,IRAP,MVCD4,Anakinra,IL1 inhibitor,Interleukin-1 receptor antagonist protein,F630041P17Rik,ICIL 1RA,ICIL1RA,IL1RN (IL1F3),Interleukin 1 receptor antagonist,Intracellular IL 1 receptor antagonist type II,Intracellular interleukin 1 receptor antagonist (icIL 1ra),MGC10430,Type II interleukin 1 receptor antagonist
- Application:
- Flow Cytometry, IF, ICC
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human IL-1RA protein
- Clone:
- A880
- Uniprot:
- P18510
- Synonyms:
- DIRA;ICIL-1RA;IL-1ra;IL-1ra3;IL-1RN;IL1 inhibitor;IL1F3;IL1RA;interleukin-1 receptor antagonist protein;intracellular IL-1 receptor antagonist type II;intracellular interleukin-1 receptor antagonist (icIL-1ra);IRAP;MVCD4;type II interleukin-1 receptor antagonist
- Extra Details:
- IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells, but reportedly will not block binding to the type II receptor on murine pre-B cell lines. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Currently, pre-clinical and clinical studies are underway to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.
- Shipping Conditions:
- Blue Ice