AN200026P
Cystatin E/CST6 Monoclonal Antibody
Size
£311.40
Was £346.00
- SKU:
- AN200026P
- Additional Names:
- CST 6,Cystatin 6,Cystatin E,Cystatin E/M,Cystatin M,Cystatin M/E,Cystatin6,Cystatin-6,CystatinE,Cystatin-E,CystatinM,Cystatin-M,Cysteine proteinase inhibitor,CYTM,CST6
- Application:
- IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human Cystatin E / CST6 protein
- Clone:
- A870
- Uniprot:
- Q15828
- Synonyms:
- cystatin 6;cystatin M/E;Cystatin-6;cystatin-E;cystatin-M;cysteine proteinase inhibitor;ECTD15
- Extra Details:
- Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.
- Shipping Conditions:
- Blue Ice