AN009730
Purified Anti-Human TIGIT Antibody[A15153G], Functional Grade
Size
£80.10
Was £89.00
- SKU:
- AN009730
- Additional Names:
- VSTM3,WUCAM,VSIG,VSTM,V-set and transmembrane domain-containing protein,V-set and immunoglobulin domain-containing protein,VSIG9,VSTM3,WUCAM,T-cell immunoreceptor with Ig and ITIM domains,V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3,TIGIT
- Application:
- Flow Cytometry
- Concentration:
- >= 1 mg/ml
- Purification:
- protein a/g purified
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
- Immunogen:
- Recombinant Human TIGIT protein
- Clone:
- A15153G
- Uniprot:
- Q495A1
- Synonyms:
- T-cell immunoreceptor with Ig and ITIM domains;V-set and immunoglobulin domain containing 9;V-set and immunoglobulin domain-containing protein 9;V-set and transmembrane domain containing 3;V-set and transmembrane domain-containing protein 3;VSIG9;VSIG9, VSTM3;VSTM3;Washington University cell adhesion molecule;WUCAM
- Extra Details:
- T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a negative regulator of NK and T cell activation. Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
- Shipping Conditions:
- Blue Ice