PE Anti-Mouse Ly-6A/E (Sca-1) Antibody[E13-161.7]

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£65.70

Was £73.00

SKU:: AN00924D
Additional Names:: Sca-1
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: Ly-6A/E
Clone:: E13-161.7
Uniprot:: P05533
Synonyms:: Ly-6A;Ly-6A.2;Ly-6A/E;Ly-6E.;Ly-6E.1;lymphocyte antigen 6A-2/6E-1;Sc;Sca;Sca-1;Sca1;stem cell antigen 1;T;T-cell-activating protein;TAP
Extra Details:: Ly-6A/E is an 18 kD member of the Ly-6 multigene family also known as Sca-1. Ly6A/E is a glycosylphosphatidylinositol (GPI)-linked protein expressed on hematopoietic stem cells. In mice expressing the Ly-6.2 haplotype (e.g., AKR, C57BL, C57BR, DBA/2, SJL, SWR, and 129), Ly-6A/E is also expressed on peripheral B lymphocytes and thymic and peripheral T lymphocytes. Strains expressing the Ly-6.1 haplotype (e.g., BALB/c, CBA, C3H/He, DBA/1, and NZB) have low Ly-6A/E expression on resting peripheral lymphocytes. The expression of Ly-6A/E on lymphocytes is upregulated upon activation from both Ly6.1 and Ly6.2 haplotype mice. Ly-6A/E is thought to be involved in the regulation of both T and B cell responses. The E13-161.7 antibody has been reported to be useful for immunohistochemical staining of frozen sections, immunoprecipitation, flow cytometry, and complement-mediated cytotoxicity.