APC Anti-Human CD32 Antibody[MDE-8]

Size

£127.80

Was £142.00

SKU:: AN00757E
Additional Names:: FCR II,FcG GammaRII
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Mouse
Reactivities:: Human
Buffer:: PBS
Immunogen:: CD32
Clone:: MDE-8
Uniprot:: P31995
Synonyms:: CD32;CD32A;CD32C;CDw32;Fc fragment of IgG, low affinity IIa, receptor (CD32);Fc fragment of IgG, low affinity IIc, receptor for (CD32);Fc gamma receptor IIC;Fc gamma receptor RIIa3;Fc-gamma RII-c;fc-gamma-RIIa;fc-gamma-RIIc;FCG2;FcGR;FCGR2;FCGR2A1;fcRII-a;FCRIIC;IGFR2;igG Fc receptor II-a;IgG Fc receptor II-c;Immunoglobulin G Fc receptor II;immunoglobulin G Fc receptor II-c;low affinity immunoglobulin gamma Fc region receptor II-a;low affinity immunoglobulin gamma Fc region receptor II-c
Extra Details:: CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcG GammaRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).