AN007150L
B7-2/CD86 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN007150L
- Additional Names:
- Activation B7-2 antigen,B72,B7-2,B-lymphocyte activation antigen B7-2,BU63,CD86 antigen,CD86 molecule,CD86,CTLA-4 counter-receptor B7.2,FUN-1,LAB72,MGC34413,T-lymphocyte activation antigen CD86,CD28LG2B7-2 antigen),CD28 antigen ligand 2
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Rat B7-2/CD86 protein expressed by Mammalian
- Uniprot:
- O35531
- Synonyms:
- B7-2;cd86 antigen;membrane glycoprotein;T-lymphocyte activation antigen CD86
- Extra Details:
- B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily.
- Shipping Conditions:
- Blue Ice