AN006890L
IL-17C Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN006890L
- Additional Names:
- IL17C,CX2,IL-17C,Cytokine CX2,IL 17C,IL 21,Interleukin 17C,Interleukin-17C
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse IL-17C protein expressed by E.coli
- Uniprot:
- Q8K4C5
- Synonyms:
- cytokine CX2;IL-1;IL-17C;interleukin-17C
- Extra Details:
- The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have also been reported. Mouse IL-17C cDNA encodes a 194 amino acid (aa) protein with a putative 14 aa signal peptide. Although there are no potential N-linked glycosylation sites, it is reportedly glycosylated. IL-17C shares from 15%-30% aa sequence identity with other IL-17 family members. Mouse and human IL-17C share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) in an adult prostate and fetal kidney libraries. IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B. Human IL-17C is active on mouse cells.
- Shipping Conditions:
- Blue Ice