AN006880L
Pentraxin 3/TSG-14 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN006880L
- Additional Names:
- Tsg,PTX,Tsg14,Ptx3,alpha-induced protein 5,long,pentaxin-related gene,Pentaxin-related protein PTX3,Pentraxin 3,pentraxin-3,pentraxin-related gene,pentraxin-related protein PTX3,rapidly induced by IL-1 beta,TNF alpha-induced protein 5,TNFAIP5,TSG-14,tumor necrosis factor
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse Pentraxin 3/TSG-14 protein expressed by E.coli
- Uniprot:
- P48759
- Synonyms:
- AI607804;pentaxin related;pentaxin-related protein PTX3;pentraxin 3;pentraxin-related protein PTX3;TSG-1;TSG-14;tumor necrosis factor-inducible gene 14 protein
- Extra Details:
- Pentraxin 3 (PTX3),TSG-14,was initially identified as a TNF-alpha or Il-1 beta inducible gene. It belongs to the pentraxin family,which was named originally for the homo-pentameric structure formed by its members. The pentraxin family is divided into two subfamilies: the "short" and the "long" pentraxins with approximate molecular weights of 25 kDa and 50 kDa,respectively. TSG-14 is a member of the long pentraxin subfamily,which also includes the Xenopus laevis Xl-PXN1,the guinea pig apexin/p50,the rat neuronal pentraxin I (NPI) and NPR,the human neuronal pentraxin II (NPTX2) and the human neuronal activity-related pentraxin.Mature secreted TSG-14 contains a pentaxin-like domain at its carboxy-terminus that shares 23-28% amino acid (aa) sequence similarity to C-reactive protein (CRP) and serum amyloid P component (SAP),which belongs to the short pentraxin subfamily. However,the N-terminal sequence of TSG-14 does not share aa sequence homology with any of the "short" pentaxins. Unlike CRP and SAP,which forms pentamers only,TSG-14 forms both pentameric and higher ordered oligomers. Similarly to CRP and SAP,TSG-14 binds to the complement cascade component C1q. However,TSG-14 does not bind to phosphoethanolamine,phosphocholine,or high pyruvate agarose,which are known ligands for CRP and SAP. TSG-14 is a marker of the acute phase response and is highly expressed in advanced atherosclerotic plaques. While CRP and SAP are primarily produced in the liver,TSG-14 expression is strongly up regulated by TNF-alpha,Il-1 beta,and bacterial lPS in peripheral fibroblasts,endothelial cells,and macrophages.
- Shipping Conditions:
- Blue Ice