AN006840L
DPP4/CD26 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN006840L
- Additional Names:
- DPP,Adenosine Deaminase Complexing Protein,ADCP,ADABP,ADCP2,Adenosine Deaminase Complexing Protein 2,DPPIV,TP103,Cd26,Dpp4,Dipeptidyl peptidase IV (DPP IV), THAM
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse DPP4/CD26 protein expressed by Mammalian
- Uniprot:
- P28843
- Synonyms:
- Cd26;dipeptidyl peptidase 4;dipeptidyl peptidase IV;Dpp;DPP IV;Dpp-4;T-cell activation antigen CD26;THA;THAM;thymocyte-activating molecule
- Extra Details:
- Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
- Shipping Conditions:
- Blue Ice