AN006100L
CTLA4 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN006100L
- Additional Names:
- Ctla4,Ly-56,GRD,Cytotoxic T-lymphocyte protein,Cytotoxic T-lymphocyte-associated antigen,IDDM,CELIAC,CELIAC3,CTLA-4,Cytotoxic T-lymphocyte protein 4,Cytotoxic T-lymphocyte-associated antigen 4,GRD4,GSE,IDDM12,Cd152,Ctla4, Ly-56
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse CTLA4 protein expressed by Mammalian
- Uniprot:
- P09793
- Synonyms:
- Cd152;CD152 antigen;Ctla;Ctla-4;cytotoxic T-lymphocyte protein 4;cytotoxic T-lymphocyte-associated antigen 4;Ly-5;Ly-56
- Extra Details:
- CTLA-4 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. CTLA-4 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CTLA-4 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CTLA-4 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2. CTLA-4 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CTLA-4 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CTLA-4 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with 20-100-fold higher affinity than CD28. The physiological role of CTLA-4 in T cell costimulation is currently being studied.
- Shipping Conditions:
- Blue Ice