AN006060L
CD74 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN006060L
- Additional Names:
- CD74 antigen (invariant polypeptide of major histocompatibility complex,classII antigen-associated),CD74 antigen,CD74 molecule,major histocompatibility complex,class II invariant chain,CD74,CLIP,DHLAG,DHLAGgamma chain of class II antigens,HLA class II histocompatibility antigen gamma chain,HLADG,HLA-DR antigens-associated invariant chain,HLA-DR-gamma,Ia antigen-associated invariant chain,Ia-associated invariant chain,Ia-gamma,Ii,INVG34,MHC HLA-DR gamma chain,p33
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human CD74 protein expressed by E.coli
- Uniprot:
- P04233
- Synonyms:
- CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated);CD74 molecule, major histocompatibility complex, class II invariant chain;DHLAG;gamma chain of class II antigens;HLA class II histocompatibility antigen gamma chain;HLA-DR antigens-associated invariant chain;HLA-DR-gamma;HLADG;Ia antigen-associated invariant chain;Ia-associated invariant chain;Ia-GAMMA;II;MHC HLA-DR gamma chain;p33
- Extra Details:
- Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.1 Publication Isoform p41 Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.
- Shipping Conditions:
- Blue Ice