Bcl-2 Polyclonal Antibody

Size

£120.60

Was £134.00

SKU:: AN006000L
Additional Names:: PPP1R,PPP1R50,Bcl-2,Bcl2
Application:: IHC
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
Immunogen:: Recombinant Rat Bcl-2 protein expressed by E.coli
Uniprot:: P49950
Synonyms:: apoptosis regulator Bcl-2;B cell lymphoma 2 associated oncogene;B-cell CLL/lymphoma 2;B-cell leukemia/lymphoma 2;Bcl-2;Bcl-2alpha;Bcl2-like protein
Extra Details:: BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.