AN005930L
TNF RI/TNFRSF1A Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN005930L
- Additional Names:
- CD120a,FPF,MS5,p55-R,p60,TBP1,TNFAR,TNFR1,TNFR1-d2,TNFR55,TNF-R55,TNFR60,TNF-R-I,TBP,TNFalpha-R,TNF-alphaR,TNFRp,TNFR1-d,FPF,MS5,p55,p55-R,p60,TBP1,TNFalpha-R1,TNF-alphaR1,TNFAR,Tnfr,TNF-R,TNF-R1,TNFR1-d2,TNFR55,TNF-R55,TNFR60,TNFRI,TNF-R-I,TNFRp55,Tnfr-1,Tnfr1,Tnfrsf1a,CD120a,TNFR-I, p55, TNFRSF1a
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse TNF RI/TNFRSF1A protein expressed by E.coli
- Uniprot:
- P25118
- Synonyms:
- CD120;CD120a;FPF;p5;p55;p55-R;p60;TN;Tnf;TNF receptor alpha chain;TNF-;TNF-a;TNF-alpha-R1;TNF-alphaR1;TNF-R;TNF-R-I;TNF-R1;TNF-R55;TNF-RI;TNFal;TNFalpha-R1;TNFAR;TNFR;Tnfr-2;TNFR-I;Tnfr1;TNFR60;TNFRI;TNFRp55;tumor necrosis factor receptor 1;tumor necrosis factor receptor superfamily member 1A;tumor necrosis factor receptor type I
- Extra Details:
- TNF-A Alpha is an important cytokine produced by numerous cell types, including neutrophils, activated lymphocytes, macrophages, and NK cells. It plays a critical role in inflammatory responses and apoptosis. TNF-A Alpha exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-A Alpha is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells. Antagonists to TNF-A Alpha have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders. The two receptors for TNF-A Alpha, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses. In most cases cytotoxicity elicited by TNF has been reported to act through TNF-R1. Cytotoxicity is mediated by a "death domain" with the intracellular region of the receptor that binds to the death domain adaptor protein TRADD and triggers the activation of caspases (8). Soluble forms of both receptors have also been characterized which can bind TNF-A Alpha and may play an important role in immune disorders.
- Shipping Conditions:
- Blue Ice