AN005920L
IL-17A Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN005920L
- Additional Names:
- CTLA8,CTLA-8,CTLA8 cytotoxic T-lymphocyte-associated serine esterase 8,Cytotoxic T-lymphocyte-associated antigen 8,IL17,IL-17,IL17A,IL-17A,IL-17A cytotoxic T-lymphocyte-associated protein 8,interleukin-17A,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8),interleukin 17A
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse IL-17A protein expressed by E.coli
- Uniprot:
- Q62386
- Synonyms:
- Ctl;Ctla;Ctla-8;Ctla8;cytotoxic T-lymphocyte-associated antigen 8;Il;IL-;IL-17;IL-17A;Il17;interleukin-17A
- Extra Details:
- Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20 kDa glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. The six IL-17 cytokines (IL-17A-F)are encoded by separate genes but adopt a conserved cystine knot fold. Mature rat IL-17A shares 60% and 89% amino acid sequence identity with human and mouse IL-17A, respectively. IL-17A is secreted by Th17 cells, gamma /D Delta T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. It forms disulfide-linked homodimers as well as disulfide-linked heterodimers with IL-17F. IL-17A exerts its effects through the transmembrane IL-17RA in complex with IL-17RC or IL-17RD. Both IL-17RA and IL-17RC are required for responsiveness to heterodimeric IL-17A/F. IL-17A promotes protective mucosal and epidermal inflammation in response to microbial infection. It induces chemokine production, neutrophil influx, and the production of antibacterial peptides. IL-17A/F likewise induces neutrophil migration, but IL-17F does not. IL-17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF-alpha induced shock. In contrast, it can protect against the progression of colitis by limiting chronic inflammation. IL-17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity. IL-17A has been shown to exert either tumorigenic or anti-tumor effects.
- Shipping Conditions:
- Blue Ice