AN005880L
Nesfatin-1/Nucleobindin-2 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- AN005880L
- Additional Names:
- DNA-binding protein NEFA, NEFA, NEFAGastric cancer antigen Zg4, Nesfatin1, Nesfatin-1, NUCB2, nucleobindin 2, Nucleobindin-2, nucleobinding 2
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human Nesfatin-1/Nucleobindin-2 protein expressed by E.coli
- Uniprot:
- P80303
- Synonyms:
- DNA-binding protein NEFA;epididymis secretory protein Li 109;gastric cancer antigen Zg4;HEL-S-109;NEFA;nesfatin 1;novel DNA binding/EF-hand/leucine zipper protein;nucleobindin-2;nucleobinding 2;prepronesfatin
- Extra Details:
- Nesfatin-1 (NEFA Encoded Satiety and Fat-influencing protein 1) is a secreted, 10 kDa peptide derived from the translation product of the NUCB2 gene. Nesfatin-1 is associated with neurons involved in feeding (ARH and PVH) and fluid intake (SON and PVH), in beta cells of the pancreas, and in adipocytes. Its presence peripherally has an anorexigenic effect. Mature human Nesfatin-1 is 82 amino acids (aa) in length. It is the secreted N-terminus of a larger, intracellular 420 aa precursor termed NEFA/Nucleobindin-2/NUCB2. NUCB2 contains a signal sequence (aa 1- 24), Nesfatin-1 (aa 25-106), a DNA-binding site (aa 171-223), and two EF-hand regions (aa 241-276 and 293-328). Intracellular uncleaved NUCB2 is 45-50 kDa in size. There is a potential for multiple cleavages, generating Nesfatin-2 (aa 109-187) and Nesfatin-3 (aa 190-420). Human Nesfatin-1 shares 85% aa identity with mouse Nesfatin-1.
- Shipping Conditions:
- Blue Ice