PE Anti-Human/Monkey/Mouse Integrin B Beta7 Antibody[FIB504]

Size

£126.90

Was £141.00

SKU:: AN00571D
Additional Names:: VI 6T-101,VI A024
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Human
Buffer:: PBS
Immunogen:: Integrin β7
Clone:: FIB504
Uniprot:: P26010, P26011
Synonyms:: gut homing receptor beta subunit;integrin beta 7 subunit;integrin beta-7;integrin beta-P;Ly69;M290 IEL antigen
Extra Details:: Integrin B Beta7 is a 130 kD glycoprotein also known as integin B Betap. It is a member of the Ig superfamily. In association with integrin A Alpha4 or A AlphaE chain, B Beta7 forms A Alpha4/B Beta7 or A AlphaE/B Beta7 heterodimer. A Alpha4/B Beta7 (CD49d/B Beta7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. A AlphaE/B Beta7 (CD103/B Beta7,A AlphaIEL/B Beta7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/B Beta7 complex is thought to play a role in lymphocyte retention via interaction with its ligand E-Cadherin.