AN005350L
PCNA Monoclonal Antibody
Size
£87.30
Was £97.00
- SKU:
- AN005350L
- Additional Names:
- Proliferating cell nuclear antigen,PCNA,Cyclin
- Application:
- IHC, WB, IP
- Concentration:
- 1 mg/ml
- Purification:
- Protein A/G Purification
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant human PCNA protein expressed by E.coli
- Clone:
- 9C6
- Uniprot:
- P12004
- Synonyms:
- ATLD2;cyclin;DNA polymerase delta auxiliary protein;proliferating cell nuclear antigen
- Extra Details:
- Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
- Shipping Conditions:
- Blue Ice