AN00421E
APC Anti-Human HLA-DQ Antibody[1a3]
Size
£83.70
Was £93.00
- SKU:
- AN00421E
- Additional Names:
- MHC class II DQ monomorphic antigen,MHC II
- Application:
- Flow Cytometry
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- HLA-DQ
- Clone:
- 1a3
- Uniprot:
- P01906
- Synonyms:
- CELIAC1;DC-1 alpha chain;DC-alpha;DQ-A1;DQA1;DX alpha chain;DX-ALPHA;HLA class II histocompatibility antigen DQ alpha chain;HLA class II histocompatibility antigen, DQ alpha 1 chain;HLA class II histocompatibility antigen, DQ alpha 2 chain;HLA class II histocompatibility antigen, DQ(6) alpha chain;HLA-DCA;HLA-DQA;HLA-DQA1;HLA-DXA;HLADQA2;MHC class I antigen;MHC class II antigen;MHC class II antigen DQA1;MHC class II DQ alpha chain;MHC class II DQA1;MHC class II DQA2;MHC class II HLA-DQ-alpha-1;MHC class II protein;MHC HLA-DQ alpha;truncated MHC class II antigen
- Extra Details:
- HLA-DQ is also known as MHC class II DQ monomorphic antigen. The major histocompatibility complex is composed of two heterodimeric glycoproteins (A Alpha and B Beta chains) with apparent molecular weights of 27 and 32 kD. In contrast to other MHC class II molecules, both polypeptide chains of HLA-DQ are polymorphic, with the A Alpha chain showing an extremely high degree of polymorphism. HLA-DQ is expressed on B cells in the peripheral blood, and weakly expressed on activated T cells and some monocytes. HLA-DQ is absent on hematopoietic progenitors, resting T cells, erythrocytes, and platelets. HLA-DQ is expressed after HLA-DR and HLA-DP in hematopoietic development. HLA-DQ presents peptide fragments mainly from degraded intravesicular and extracellular proteins to CD4+ T lymphocytes. Specific alleles of HLA-DQ have been linked to the pathogenesis of several autoimmune diseases (including diabetes), both as a susceptibility and resistance factor depending on the particular polymorphism.
- Shipping Conditions:
- Blue Ice