APC Anti-Mouse CD122 Antibody[TM-Beta 1]

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£72.90

Was £81.00

SKU:: AN00418E
Additional Names:: IL-2 Receptor B Beta chain,IL-2RB Beta
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD122
Clone:: TM-Beta 1
Uniprot:: P16297
Synonyms:: CD122;high affinity IL-2 receptor subunit beta;IL-15 receptor beta chain;IL-15R;IL-15Rbeta;IL-2 receptor beta chain;IL-2 receptor subunit beta;IL-2/15 receptor-beta;Il-2/15Rbeta;Il-2R;IL-2R subunit beta;IL-2RB;Il-2Rbeta;IL15R;IL15Rbeta;interleukin-2 receptor subunit beta;p70;p70-75
Extra Details:: CD122 is a 70-75 kD IL-2 receptor B Beta chain also known as IL-2RB Beta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2RB Beta chain can combine with either the common G Gamma subunit (G Gammac, CD132) alone or with the G Gammac subunit and the IL-2RA Alpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The TM-B Beta1 antibody does inhibit IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.