APC Anti-Mouse CD8a Antibody[YTS 105.18]

Size

£60.30

Was £67.00

SKU:: AN00331E
Additional Names:: T8,Lyt2,Ly-2
Application:: Flow Cytometry
Storage Conditions:: 2-8[o]C Do not freeze. Protect from light.
Supplier:: Elabscience
Host:: Rat
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: CD8a
Clone:: YTS 105.18
Uniprot:: P01731
Synonyms:: BB154331;Ly-;Ly-2;Ly-3;Ly-35;Ly-B;Lyt-;Lyt-2;Lyt-2.1 lymphocyte differentiation antigen (AA at 100);T-cell surface glycoprotein CD8 alpha chain;T-cell surface glycoprotein Lyt-2
Extra Details:: CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked A Alpha and B Beta chains that form the A Alpha(CD8a)/B Beta(CD8b) heterodimer and A Alpha/A Alpha homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 A Alpha/B Beta heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR A Alpha/B Beta T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 A Alpha/A Alpha homodimer is expressed on a subset of G Gamma/D Delta TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.