Y12821H
Recombinant Human IL-33
Size
£437.00
- SKU:
- Y12821H
- Additional Names:
- IL33, DV27, C9ORF26, IL1F11, NFHEV, DKFZp586H0523, DVS27, NFEHEV, RP11-575C20.2
- Application:
- Functional Assay
- Molecular Weight:
- 18.1 kDa
- Purity:
- ≥95% by SDS-PAGE
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Host:
- E. coli
- ABP:
- No Import Docs
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% Mannitol and 0.01% Tween 80, pH7.4
- Format:
- Lyophilized powder
- Extra Details:
- IL-33 (Interleukin-33) is a cytokine belonging to the IL-1 family and is mainly expressed by epithelial cells, endothelial cells, and fibroblasts. It signals through the ST2 (IL-1RL1) receptor in complex with IL-1RAcP, activating downstream pathways such as NF-κB and MAPK to initiate type 2 immune responses. Functionally, IL-33 acts as an “alarmin” released upon tissue damage, promoting activation of Th2 cells, ILC2s, mast cells, and eosinophils, and inducing the production of IL-5 and IL-13. In *in vitro* cell and organoid models, IL-33 is commonly used to simulate tissue injury–associated inflammation and type 2 immune microenvironments, particularly in studies of allergy, asthma, and epithelial–immune interactions.
- Shipping Conditions:
- Blue Ice