Y07201
Recombinant Human TPO
Size
£484.00
- SKU:
- Y07201
- Additional Names:
- Thrombopoietin， MPL Ligand， MGDF
- Application:
- Functional Assay
- Molecular Weight:
- 18.6 kDa
- Purity:
- ≥95% by SDS-PAGE
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Host:
- Hamster
- ABP:
- No Import Docs
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% mannitol and 0.01% Tween 80, pH 7.4
- Format:
- Lyophilized powder
- Extra Details:
- Thrombopoietin (TPO) is a crucial hematopoietic growth factor belonging to the hematopoietic cytokine family. It serves as a central regulator of megakaryocyte development and platelet production, stimulating the differentiation of hematopoietic stem cells into the megakaryocytic lineage and ultimately leading to thrombopoiesis. Upon binding to its receptor c-Mpl, TPO activates signaling pathways such as JAK/STAT and PI3K/AKT, promoting the survival, proliferation, and long-term self-renewal of hematopoietic stem cells. When used in combination with other cytokines—such as SCF, IL-3, and IL-6—TPO enhances the expansion efficiency of hematopoietic stem and progenitor cells. Through its unique structural specificity, TPO precisely activates downstream signaling cascades and plays a core role in controlling the fate of hematopoietic stem cells and megakaryocytes in cell culture systems. It is widely regarded as a cornerstone molecule in hematological research and clinical applications.
- Shipping Conditions:
- Blue Ice