Y03301
Recombinant Human Noggin
Size
£263.00
- SKU:
- Y03301
- Additional Names:
- Noggin, NOG, SYM1, SYNS1
- Application:
- Functional Assay
- Molecular Weight:
- 23.0 kDa
- Purity:
- ≥95% by SDS-PAGE
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Host:
- Hamster
- ABP:
- No Import Docs
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% mannitol and 0.01% Tween 80, pH 7.4
- Format:
- Lyophilized powder
- Extra Details:
- Noggin, a secreted protein belonging to the TGF-β superfamily, functions as an endogenous antagonist of bone morphogenetic proteins (BMPs) and plays a key regulatory role in embryonic development, particularly in neural patterning and bone formation. By inhibiting BMP signaling—especially that of BMP4, which normally suppresses neural differentiation—Noggin promotes the differentiation of stem cells (such as embryonic stem cells or induced pluripotent stem cells) into neural precursor cells or neurons. It is therefore commonly used in neural differentiation media for stem cells. Under certain culture conditions, Noggin can also act synergistically with other factors (e.g., FGF2, TGF-β) to help maintain stem cell self-renewal and prevent spontaneous differentiation. Additionally, Noggin is frequently employed in cerebral or neural organoid culture systems to facilitate the formation of neuroepithelial structures.
- Shipping Conditions:
- Blue Ice