Y03101F
Recombinant Bovine/Porcine LR3 IGF-1
Size
£120.00
- SKU:
- Y03101F
- Additional Names:
- LR3 IGF-1，R3 IGF1，LONG R3 IGF-1，IGF-1 LR3，LR3 IGF-I
- Application:
- Functional Assay
- Molecular Weight:
- 9.0 kDa
- Purity:
- ≥95% by SDS-PAGE
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Host:
- Hamster
- ABP:
- No Import Docs
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% Mannitol and 0.01% Tween 80, pH 7.4
- Format:
- Lyophilized powder
- Extra Details:
- IGF-1 LR3 (Long Arginine 3-IGF-1), a modified analog of IGF-1, features a 13-amino acid extension at the N-terminus and the removal of the third amino acid (glutamic acid). These modifications significantly reduce its affinity for IGF-binding proteins (IGFBPs), resulting in enhanced stability and prolonged activity in culture. In cell culture, IGF-1 LR3 is widely used to promote cell growth, proliferation, and differentiation—particularly in myoblasts, chondrocytes, stem cells (e.g., mesenchymal stem cells), and neural cells. It also exhibits anti-apoptotic effects by activating the Akt pathway and suppressing pro-apoptotic proteins, thereby improving cell survival. This is especially critical under serum-free or low-serum culture conditions. In such environments, IGF-1 LR3 can partially substitute for serum to support the growth of specific cell types, including CHO cells and stem cells.
- Shipping Conditions:
- Blue Ice