Y02812H
Recombinant Human IL-18, His Tag
Size
£350.00
- SKU:
- Y02812H
- Additional Names:
- IL-18, Interleukin-18, IL18, IL-1 gamma, IGIF, IL1F4, IL-1F4
- Application:
- Functional Assay
- Molecular Weight:
- 18.2 kDa
- Purity:
- ≥95% by SDS-PAGE
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Host:
- Yeast
- ABP:
- No Import Docs
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing 10mM PB, 5% Trehalose and 0.01% Tween 80, pH7.4
- Format:
- Lyophilized powder
- Extra Details:
- IL-18 (Interleukin-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. It signals through a heterodimeric receptor composed of IL-18Rα (binding chain) and IL-18Rβ (signaling chain), leading to activation of NF-κB and MAPK pathways. IL-18 exerts immunomodulatory functions by promoting Th1 immune responses and, in synergy with IL-12, induces IFN-γ production in T cells and NK cells, thereby enhancing cell-mediated immunity (e.g., in anti-tumor or anti-infection responses). Additionally, it activates NK cells, boosting their cytotoxicity and cytokine secretion. Under specific conditions—such as in combination with IL-23—IL-18 can also promote Th17 differentiation and has been implicated in models of autoimmune diseases.
- Shipping Conditions:
- Blue Ice