Y02501
Recombinant Human IL-10
Size
£437.00
- SKU:
- Y02501
- Additional Names:
- CSIF, IL-10, IL10A, TGIF, B-TCGF, GVHDS, MGC126450, MGC126451, RP11-262N9.1, Interleukin-10
- Application:
- Functional Assay
- Molecular Weight:
- 18.6 kDa
- Purity:
- ≥95% by SDS-PAGE
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Host:
- Hamster
- ABP:
- No Import Docs
- Formulation:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% Mannitol, 0.01%Tween 80, pH7.4
- Format:
- Lyophilized powder
- Extra Details:
- IL-10 (Interleukin-10) is an important anti-inflammatory cytokine primarily produced by immune cells—such as T cells, B cells, monocytes, macrophages, and dendritic cells—as well as certain non-immune cells including keratinocytes. In cell culture, IL-10 suppresses the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6, and IL-12), downregulates M1 macrophage activation, and promotes polarization toward M2 (anti-inflammatory) macrophages. In immune regulation, IL-10 inhibits the proliferation and function of T cells—particularly Th1 and Th17 subsets—while enhancing the immunosuppressive activity of regulatory T cells (Tregs). In macrophage or dendritic cell cultures, IL-10 can be used to induce an anti-inflammatory phenotype and mimic an immune-tolerant microenvironment similar to that found in vivo.
- Shipping Conditions:
- Blue Ice