Y02321B
Recombinant Bovine IL-6
Size
£202.00
- SKU:
- Y02321B
- Additional Names:
- IL6, Interleukin-6, BSF2, HSF, IFNB2
- Application:
- Functional Assay
- Molecular Weight:
- 20.7 kDa
- Purity:
- ≥95% by SDS-PAGE
- Storage Conditions:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Supplier:
- East-Mab Biomedical
- Host:
- E. coli
- ABP:
- No Import Docs
- Formulation:
- Lyophilized from a 0.2 um filtered solution containing PBS, 5% mannitol and 0.01% Tween 80, pH 7.4
- Format:
- Lyophilized powder
- Extra Details:
- IL-6 (Interleukin-6) is a pleiotropic cytokine secreted by various cell types, including T cells, B cells, macrophages, fibroblasts, and endothelial cells. It plays a critical role in immune regulation, inflammatory responses, hematopoiesis, metabolism, and tissue repair. Signaling is mediated through a complex composed of gp130 and the IL-6 receptor (IL-6R), activating pathways such as JAK/STAT, MAPK, and PI3K. In immune cell cultures—including T cells, B cells, and macrophages—IL-6 promotes Th17 cell differentiation (associated with autoimmunity), suppresses regulatory T cell (Treg) function, and stimulates B cell differentiation into plasma cells, thereby enhancing antibody production. In hematopoietic stem cell cultures, IL-6 acts synergistically with other cytokines (e.g., IL-3 and SCF) to promote the proliferation and differentiation of hematopoietic progenitors, particularly along the megakaryocyte and granulocyte lineages.
- Shipping Conditions:
- Blue Ice