Recombinant Human IL-3

Size

£386.00

SKU:: Y02121H
Additional Names:: IL3, MCGF, MGC79398, MGC79399, MULTI-CSF, Interleukin-3
Application:: Functional Assay
Molecular Weight:: 15.1 kDa
Purity:: ≥95% by SDS-PAGE
Storage Conditions:: 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Supplier:: East-Mab Biomedical
Host:: E. coli
ABP:: No Import Docs
Formulation:: Lyophilized from a 0.22 um filtered solution containing 10mM PB, 5% Trehalose and 0.01% Tween 80, pH7.4
Format:: Lyophilized powder
Extra Details:: IL-3 (Interleukin-3), also known as Multi-CSF, is a cytokine secreted by activated T cells, mast cells, and natural killer (NK) cells. It exerts its function by binding to the IL-3 receptor complex, composed of IL-3Rα (CD123) and the common beta chain (CD131), thereby activating downstream signaling pathways such as JAK/STAT, MAPK, and PI3K/Akt. IL-3 plays a critical regulatory role in both hematopoietic and non-hematopoietic systems. It promotes the survival and proliferation of hematopoietic stem and progenitor cells, and supports the growth of myeloid cells, including granulocytes, monocytes, and mast cells. Furthermore, IL-3 enhances the antigen-presenting capacity of dendritic cells (DCs) and stimulates B cell proliferation and antibody secretion.