RGK60001
Anti-DNA-RNA Hybrid Antibody(S9.6)
Size
£384.00
- SKU:
- RGK60001
- Application:
- ChIP, IF, ICC, IP, Dot blot
- Concentration:
- 0.58 mg/ml
- Physical State:
- Liquid
- Purity:
- >95%
- Purification:
- Protein A/G purified from cell culture supernatant.
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- AntibodySystems
- Host:
- Mouse
- Buffer:
- 0.01M PBS, pH 7.4.
- Immunogen:
- DNA-RNA Hybrid
- Clone:
- S9.6
- Extra Details:
- DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.
- Shipping Conditions:
- Blue Ice