EHJ24002
Recombinant Human PCSK9 (Asp374Tyr) Protein, C-His
Size
£232.00
- SKU:
- EHJ24002
- Additional Names:
- Proproteinconvertasesubtilisin/kexintype9,Subtilisin/kexin-likeproteasePC9,NARC-1,PC9,Proproteinconvertase9,Neuralapoptosis-regulatedconvertase1,NARC1,PCSK9
- Application:
- ELISA, SDS-PAGE, WB
- Physical State:
- Lyophilized
- Molecular Weight:
- 75.30kDa
- Purity:
- >90% as determined by sds-page.
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- AntibodySystems
- Buffer:
- LyophilizedfromasolutioninPBSpH7.4,1mMEDTA,4%Trehalose,1%Mannitol.
- Species:
- Human
- Uniprot:
- Q8NBP7
- Synonyms:
- convertase subtilisin/kexin type 9 preproprotein;FH3;FHCL3;HCHOLA3;LDLCQ1;NARC-1;NARC1;neural apoptosis regulated convertase 1;Neural apoptosis-regulated convertase 1;PC9;Proprotein convertase 9;proprotein convertase subtilisin/kexin type 9;subtilisin/kexin-like protease PC9
- Extra Details:
- GeneticvariationinPCSK9hasanenormousimpactonLDL-Cconcentrationinhumansandbothgain-of-function(GOF)andloss-of-function(LOF)PCSK9mutationshavebeendescribed.WhilePCSK9LOFmutationscausehypocholesterolemia,GOFmutationsareararecauseoffamilialhypercholesterolemia(FH),amonogenicdiseasecharacterizedbyveryhighlevelsofLDL-Candprematureatheroscleroticcardiovasculardisease(ASCVD).PCSK9GOFmutationsarecausativeofFH,becausetheenhancementinPCSK9functionleadstoincreasedLDLrdegradationandreducedrecyclingtothecellsurface.Asaconsequence,thereisareductioninLDLuptakeandanincreaseincirculatingLDL-Cconcentration.ThebestcharacterizedPCSK9GOFmutationisp.(Asp374Tyr)whichproducesaten-foldincreaseinLDLrdegradationbyincreasingthebindingaffinityofPCSK9totheepidermalgrowthfactor-likedomainofLDLr.ThisvariantwasdemonstratedtoinhibitLDLuptakestillataconcentration25timeslowerthanthewild-typePCSK9.
- Shipping Conditions:
- Dry Ice