WRN-H5143
Human WRN Protein, His Tag
Cannot supply to this region.
- SKU:
- WRN-H5143
- Physical State:
- Liquid
- Molecular Weight:
- 39.9 kda
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Immunogen:
- WRN
- Species:
- Human
- Uniprot:
- Q14191-1
- Synonyms:
- DNA helicase, RecQ-like type 3;Exonuclease WRN;RecQ protein-like 2
- Extra Details:
- This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
- Shipping Conditions:
- Dry Ice