Human WEE1 Protein, His Tag (active enzyme)

Cannot supply to this region.

SKU:: WE1-H5543
Physical State:: Liquid
Molecular Weight:: 51.1 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 300 mM NaCl, pH7.5
Immunogen:: WEE1
Species:: Human
Uniprot:: P30291-1
Synonyms:: Wee1A kinase
Extra Details:: WEE1 is a serine/threonine protein kinase that acts as a critical regulator of the cell cycle , particularly at the G₂/M checkpoint . It inhibits cell cycle progression by phosphorylating and inactivating CDK1 (Cyclin-Dependent Kinase 1) at Tyr15, thereby preventing premature entry into mitosis and allowing time for DNA repair.Originally identified in fission yeast, WEE1 is highly conserved in mammals and plays a key role in maintaining genomic stability. Dysregulation of WEE1 is linked to cancer progression , as its overexpression in tumors (e.g., ovarian, breast, pancreatic cancers) supports cancer cell survival by enabling DNA damage tolerance. This dependency makes WEE1 a promising therapeutic target , especially in p53-mutant cancers where inhibiting WEE1 induces synthetic lethality by forcing cells with unrepaired DNA into catastrophic mitosis.