Human USP1 & UAF1 Protein, GST Tag&Strep II Tag

Cannot supply to this region.

SKU:: US1-H85W3
Physical State:: Liquid
Molecular Weight:: 114.1 kDa & 77.8 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 150 mM NaCI, pH7.5
Immunogen:: USP1 & UAF1
Species:: Human
Uniprot:: O94782-1, Q8TAF3-1
Synonyms:: Deubiquitinating enzyme 1;p80;Ubiquitin thioesterase 1;Ubiquitin-specific-processing protease 1;USP1-associated factor 1;WD repeat endosomal protein
Extra Details:: USP1 (ubiquitin-specific protease 1) is a deubiquitinating enzyme crucial for DNA damage repair, cell cycle regulation, and protein homeostasis. Its catalytic efficiency is markedly enhanced by UAF1 (USP1-associated factor 1), a cofactor that stabilizes USP1 and directs it to nuclear substrates. Together, the USP1-UAF1 complex removes ubiquitin from key proteins such as PCNA and FANCD2, maintaining genomic stability and influencing cancer development, making it a potential therapeutic target in oncology.