Human Tyk2 Protein, His Tag

Cannot supply to this region.

SKU:: TY2-H5548
Physical State:: Liquid
Molecular Weight:: 35.2 kda
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: 50 mM Tris, 150 mM NaCl, pH7.5
Immunogen:: Tyk2
Species:: Human
Uniprot:: P29597-1
Extra Details:: Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-A Alpha, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-A Alpha and -B Beta and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.