Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag

Cannot supply to this region.

SKU:: TRA-H5259
Additional Names:: MTC|NTRK1|TRK|Trk-A|TrkA
Physical State:: Powder
Molecular Weight:: 68.2 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: Tris with Glycine, Arginine and NaCl, pH7.5
Immunogen:: TrkA
Species:: Human
Uniprot:: P04629-2
Synonyms:: gp140trk;Neurotrophic tyrosine kinase receptor type 1;p140-TrkA;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A
Extra Details:: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.