Human TOP2A / TOP2 Protein, Tag Free

Cannot supply to this region.

SKU:: TOA-H5117
Additional Names:: alpha isozyme|DNA topoisomerase 2-alpha|DNA topoisomerase II|TOP2|TOP2A
Physical State:: Liquid
Molecular Weight:: 13.0 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 0.5 M KCl, pH8.0
Immunogen:: TOP2A
Species:: Human
Uniprot:: P11388-1
Synonyms:: DNA topoisomerase II, alpha isozyme
Extra Details:: DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.