Monoclonal Anti-TNF-alpha Antibody, Mouse IgG1 (16H5) (MALS verified)

Cannot supply to this region.

SKU:: TNA-Y59
Application:: ELISA, Lateral Flow
Physical State:: Powder
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Reactivities:: Mouse
Buffer:: PBS (pH 7.4)
Immunogen:: TNF-alpha
Clone:: 16H5
Extra Details:: Tumor necrosis factor alpha (TNFA Alpha) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFA Alpha is in the regulation of immune cells. TNFA Alpha is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFA Alpha production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFA Alpha is used as an immunostimulant under the INN tasonermin. TNFA Alpha can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.