Human & Mouse TNFR1 / CD120a / TNFRSF1A (30-82 & 83-212) Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: TN1-H52H4
Physical State:: Powder
Molecular Weight:: 22.3 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: TNFR1
Species:: Human, Mouse
Uniprot:: P19438-1, P25118-1
Synonyms:: p55;p60;Tumor necrosis factor receptor 1;Tumor necrosis factor receptor type I
Extra Details:: Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).