Human TNFR1 / CD120a / TNFRSF1A Protein, His Tag, low endotoxin (MALS verified)

Cannot supply to this region.

SKU:: TN1-H5222
Additional Names:: CD120a|FPF|p55|p60|TBP1|TNF-R|TNF-R-I|TNF-R55|TNFAR|TNFR1|TNFR55|TNFR60|TNFRSF1A
Physical State:: Powder
Molecular Weight:: 21.6 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: TNFR1
Species:: Human
Uniprot:: P19438
Synonyms:: CD120a;FPF;p55;p55-R;p60;TBP1;TNF-R;TNF-R-I;TNF-R1;TNF-R55;TNF-RI;TNFAR;TNFR-I;TNFR1;TNFR55;TNFR60;tumor necrosis factor binding protein 1;Tumor necrosis factor receptor 1;tumor necrosis factor receptor superfamily member 1A;tumor necrosis factor receptor type 1;Tumor necrosis factor receptor type I;tumor necrosis factor-alpha receptor
Extra Details:: Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

Shipping Conditions:: Ambient