Biotinylated Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, Avitag[TM],His Tag (MALS verified)

Cannot supply to this region.

SKU:: TLA-C82E3
Physical State:: Powder
Molecular Weight:: 23.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS, 0.2 M Arginine, pH7.4
Immunogen:: TL1A
Species:: Non-human Primate
Uniprot:: F6S8F9-1
Synonyms:: TNF ligand-related molecule 1;Vascular endothelial cell growth inhibitor
Extra Details:: TL1A, also known as TNFSF15, is a member of the TNF superfamily. This type II transmembrane protein forms stable homotrimers via its TNF homology domain (THD) and is expressed in immune cells, including monocytes, macrophages, dendritic cells, and T cells, as well as non-immune cells like synovial fibroblasts and endothelial cells. By binding to Death Receptor 3 (DR3), TL1A modulates proliferation, activation, apoptosis, and cytokine/chemokine production in effector cells, contributing to both innate and adaptive immune homeostasis. Dysregulated TL1A expression is implicated in autoimmune diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease, making it a promising therapeutic target for conditions like ulcerative colitis and Crohn's disease.