PE-Labeled Human TIGIT Protein, His TagStar Staining

Cannot supply to this region.

SKU:: TIT-HP2H3
Physical State:: Powder
Storage Conditions:: Please refer to datasheet
Supplier:: ACRO Biosystems
Buffer:: PBS, 0.2% BSA, pH7.4
Immunogen:: TIGIT
Species:: Human
Uniprot:: Q495A1-1
Synonyms:: V-set and immunoglobulin domain-containing protein 9;V-set and transmembrane domain-containing protein 3
Extra Details:: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.