Biotinylated Human Latent TGF-beta 3 / Latent TGFB3 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: TG3-H82E6
Additional Names:: ARVD|TGF-beta3|TGFB3
Physical State:: Powder
Molecular Weight:: 48.4 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: TGF-beta 3
Species:: Human
Uniprot:: P10600-1
Extra Details:: Transforming growth factor beta 3 ( TGFB3) is also known as TGF-B Beta3, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. TGF-beta 3 is similar with TGF-beta 1 and --beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial--mesenchymal transition. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.