Human TFPI Protein, His Tag (active enzyme)

Cannot supply to this region.

SKU:: TFI-H5226
Additional Names:: EPI|LACI|TFI|TFPI|TFPI1
Physical State:: Powder
Molecular Weight:: 30.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: TFPI
Species:: Human
Extra Details:: Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N-terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C-terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C-terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.