Biotinylated Human TEM8 / ANTXR1 (T118A) Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: TE8-H82E4
Physical State:: Powder
Molecular Weight:: 36 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: TEM8/ANTXR1
Species:: Human
Uniprot:: Q9H6X2
Synonyms:: 2310008J16Rik;2810405N18Rik;anthrax toxin receptor 1;ATR;GAPO;TEM8;tumor endothelial marker 8
Extra Details:: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]