TD3-H5145
Human TDP-43 Protein, His Tag
Cannot supply to this region.
- SKU:
- TD3-H5145
- Physical State:
- Liquid
- Molecular Weight:
- 46.8 kDa
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- ABP:
- No Import Docs
- Buffer:
- 50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0
- Immunogen:
- TDP-43
- Species:
- Human
- Uniprot:
- Q13148-1
- Extra Details:
- TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.
- Shipping Conditions:
- Dry Ice