Rhesus macaque TCR & CD3E & CD3D & CD3G & CD3Z Full Length Protein Complex (VLP)

Cannot supply to this region.

SKU:: TCZ-R5213
Physical State:: Liquid
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS, Arginine, pH7.4
Immunogen:: TCR & CD3E & CD3D & CD3G & CD3Z
Species:: Non-human Primate
Extra Details:: Cluster of Differentiation 3 (CD3) is a pivotal multimeric T cell co-receptor complex essential for adaptive immune responses. Composed of epsilon (E Epsilon), gamma (G Gamma), delta (D Delta), and zeta (Z Zeta) polypeptide chains forming three distinct dimers (E EpsilonG Gamma, E EpsilonD Delta, Z ZetaZ Zeta), CD3 non-covalently associates with the T-cell receptor (TCR) to establish the critical TCR/CD3 receptor complex on T cell surfaces. Structurally, CD3 proteins belong to the immunoglobulin superfamily, featuring a transmembrane domain, an N-terminal extracellular region with immunoglobulin-like domains, and cytoplasmic tails embedded with immunoreceptor tyrosine-based activation motifs (ITAMs). These ITAMs are fundamental for initiating signal transduction upon T cell receptor engagement, thereby activating both CD4+ T helper and CD8+ cytotoxic T cells. As a defining marker of the T cell lineage, CD3's central role in T cell activation makes its modulation, via stimulating or blocking antibodies, a promising therapeutic avenue for conditions like organ transplant rejection and autoimmune diseases.