Biotinylated Human TACI / TNFRSF13B Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: TAI-H82E3
Physical State:: Powder
Molecular Weight:: 22.2 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS, 0.2 M Arginine, pH7.4
Immunogen:: TACI
Species:: Human
Uniprot:: O14836-1
Synonyms:: Transmembrane activator and CAML interactor
Extra Details:: Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B). It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells.